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In the cytosol, the trifunctional enzyme MTHFD1 catalyzes dehydrogenase, cyclohydrolase, and formyltetrahydrofolate synthetase reactions to interconvert these THF intermediates and formate, whereas in mitochondria,these interconversions are carried out by MTHFD2/MTHFD2L (dehydrogenase/cyclohydrolase) and MTHFD1L (formyltetrahydrofolate synthetase), respectively (Fig
Back in September, I spilled boiling water across my forearm while making pasta
The glutathione redox state of the matrix is maintained separately from the IMS and the cytosol Our results also imply that the IMM prevents the equilibration of the glutathione pools in matrix and IMS in vivo and in vitro , and that the matrix has to rely on its own glutathione reduction machinery for maintaining E GSH
Hines M, Gomez-Contreras PC, Rodman S, Liman S, Coleman M
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